Cardiac Research and Teaching

When our patients put their hearts in our hands, we want to do everything possible to make sure they get better. That’s why we do more than diagnose and treat cardiac problems. Our researchers are working to develop even more advanced diagnostic tools and better treatment options to offer to our patients.

Cardiac Research and Clinical Trials at UMass Memorial Medical Center

UMass Memorial Medical Center in Worcester, MA, has earned a reputation for excellence in treating coronary disease due in part to our participation in clinical trials. Our current research funding comes from the National Institutes of Health, American Heart Association and non-federal sources. Search for a trial by condition.

Our cardiac research programs focus on:

  • Prevention and behavior
  • Adherence
  • Epidemiology
  • Thrombosis
  • Interventional techniques and devices
  • Atherosclerosis
  • Cardiac arrhythmias
  • Gene therapy
  • Stem cell therapy
  • Heart failure
  • Nuclear cardiology
  • Registry programs for transluminal valve repair (aortic and mitral)

Our cardiac research and clinical trials include:

  • Assessment of the safety profile of allogeneic stems cells administered by intracoronary infusion in patients with left ventricular dysfunction and a previous heart attack
  • Studying the effects of glucose-insulin-potassium in patients in cardiac arrest as part of the NIH’s Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) trial
  • Studying the effectiveness of treatment with Apixaban versus standard medications in patients with non-valvular atrial fibrillation indicated for early cardioversion and initiation of anticoagulation
  • The Absorb IV Clinical Trial, which allows for the implantation of an investigational bioresorbable vascular scaffold (BVS) manufactured by Abbott Laboratories
  • Monitoring trends in heart failure and new medications to treat this condition
  • Determining whether a non-invasive wearable cardioverter defibrillator will reduce sudden death and/or death due to arrhythmia after a heart attack (myocardial infarction) in patients with left ventricular dysfunction
  • Exploring the safety and potential clinical benefit of a new intravenous medication (a PAR1 inhibitor) to reduce the risk of bleeding in patients undergoing coronary interventions
  • Participation in the 20-year Worcester Heart Attack Study (WHAS) to study changes in hospital fatality rates for patients with ventricular fibrillation
  • Working to reduce the risk of diabetes among Latinos as part of the Lawrence Latino Diabetes Prevention Project
  • Studying hospital related morbidity and mortality in patients with blood clots in the legs and lungs as part of the Worcester Venous Thromboembolism Study
  • Providing diet and exercise counseling to patients with coronary artery disease

Complex Aortic Aneurysm Studies

Sometimes, complex aneurysms cannot be treated by an FDA-approved device. In that case, you may qualify to take part in a research study.

We are currently enrolling people in several research studies that may allow us to treat your complex aneurysm, such as:


Each patient’s case will be evaluated. If your treatment requires the use of a research device, the specific study will be explained to you, and you will be asked to sign a study-specific consent form. You won’t be entered into a research study without your permission.

If you are included in a study, we will collect specific information about your health, the procedure, devices that are used and your long-term medical condition. The information that is collected is shared with the study sponsor and FDA. Your name is not used on these reports. We will provide more information on how we maintain your confidentiality if you decide to participate in a study.

Cardiac Training at UMass Memorial Medical Center

As an academic medical center, we work closely with the UMass Medical School, its students and residents.

We offer competitive fellowship programs in interventional cardiology, cardiovascular medicine, electrophysiology and vascular surgery, as well as a newly developed advanced interventional cardiology structural heart disease fellowship. 

One of Healthgrades America's 100 Best Hospitals for Cardiac Care seven years in a row.

Recipient of the Healthgrades Cardiac Care Excellence Award
for nine years in a row.

Healthgrades Cardiac Care Excellence Award


Recipient of Healthgrades Coronary Intervention Excellence Award for 10 years in a row. 

Coronary Excellence Award Healthgrades